#Clinical Trial
Articles tagged #Clinical Trial on Vitalspell.
Probiotics and diet together reduced gut inflammation in autistic children
Two new studies strengthen the case that probiotics combined with dietary changes can reduce intestinal inflammation in children with autism spectrum disorder — but behavioural benefits remain unproven.
Berberine derivative lowered HbA1c by 1% in 12-week diabetes trial
A phase 2 randomized trial published in JAMA Network Open found that HTD1801, an oral compound combining berberine with ursodeoxycholic acid, reduced HbA1c by 1.0 percentage point over 12 weeks. The drug also improved insulin sensitivity, lipid profiles, and liver enzyme levels, with two phase 3 trials now completed and an NDA submission planned.
Magnesium L-threonate improved cognition by 7.5 cognitive years in 6-week trial
A 6-week randomised trial in 100 adults found that 2 grams per day of magnesium L-threonate (Magtein) improved overall cognitive performance and reduced estimated brain cognitive age by 7.5 years. Sleep improvements were selective, but heart rate and heart rate variability both moved in favourable directions.
Longevity supplement NOVOS Core improved vascular aging markers in first human trial
A six-month randomized controlled trial at the University of Surrey found NOVOS Core, a 12-ingredient supplement, improved endothelial function, arterial flexibility, and blood pressure in 61 healthy adults over 40. The effect sizes rival those of structured exercise programs, but the study is modest, single-center, and not yet peer-reviewed.
Vitex agnus-castus improved oxidative stress markers and insulin resistance in PCOS trial
A 12-week randomized controlled trial of 60 women with PCOS found that 5.8 mg daily of standardized Vitex agnus-castus extract improved antioxidant capacity, reduced insulin resistance, and lowered hirsutism scores compared to placebo. The trial was published in JBRA Assisted Reproduction in January 2026.
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Caffeine within 12 hours of bedtime harms sleep, often without you noticing
A randomized crossover trial in Sleep found that 400 mg of caffeine disrupts sleep when consumed within 12 hours of bedtime, while 100 mg is safe up to four hours before bed. Most participants could not tell when caffeine was harming their sleep.
Phosphatidylserine supplement improved short-term memory in Chinese MCI trial
A 12-month RCT in 190 Chinese older adults found that a supplement containing phosphatidylserine, ALA, and Ginkgo improved short-term memory and executive function. But the combination-product design and a low PS dose make it hard to know which ingredient actually worked.
Low-dose oral NMN was safe and moved platelet counts in a phase 1/2 ITP trial
A 25-patient phase 1/2 trial published in Nature Medicine found that low-dose oral NMN was well tolerated in adults with steroid-refractory immune thrombocytopenia, with 20 percent meeting the primary platelet-response endpoint and 52 percent maintaining responses through week 8.
Nutrition timing alone not enough for night-shift metabolic health, trial finds
An 8-week crossover trial in female healthcare workers found that protein-and-nutrient-timing guidance modestly improved visceral fat percentage but did not shift inflammatory markers, gut microbiome diversity, or mental health scores. The findings suggest dietary changes alone are insufficient to reverse the metabolic effects of circadian disruption.
A high-fiber diet barely moved the rectal microbiome, except for two CRC-linked bacteria
A four-year randomized trial found that a rigorous high-fiber, high-produce, low-fat diet had almost no effect on the bacterial community living in rectal tissue, but two oral-originating bacteria previously tied to colorectal cancer dropped more in the diet group than in controls.
Lion's Mane extract showed no overall cognitive improvement in acute trial
A double-blind trial in Frontiers in Nutrition found that a single 3-gram dose of Lion's Mane fruiting body extract did not significantly improve overall cognition or mood in healthy young adults, though fine motor dexterity improved on the pegboard test.