#Longevity
Articles tagged #Longevity on Vitalspell.
Plasma Exchange Reduced Blood Microplastics 60% in First Human Study
Plasma exchange reduced circulating microplastics ~60% in high-burden patients in the first human study. Whether that improves health is still unknown.
Cold Plunges and Your Brain: What the Science Actually Shows
Cold plunges trigger a measurable surge of noradrenaline and dopamine, but the RCT evidence for long-term mental health benefits is still thin. Two recent studies clarify what the data do and do not support.
Longevity supplement NOVOS Core improved vascular aging markers in first human trial
A six-month randomized controlled trial at the University of Surrey found NOVOS Core, a 12-ingredient supplement, improved endothelial function, arterial flexibility, and blood pressure in 61 healthy adults over 40. The effect sizes rival those of structured exercise programs, but the study is modest, single-center, and not yet peer-reviewed.
What Bryan Johnson's Erection Tracking Reveals About Vascular Health
Bryan Johnson claims nighttime erections predict mortality. The medical literature confirms erectile function is an early warning for cardiovascular disease, but his personal protocol of tadalafil, Botox, and shockwave therapy goes beyond what the evidence supports.
Aged garlic compound nudges the fat-brain-muscle axis longevity researchers chase
A new Cell Metabolism paper identifies S-1-propenyl-L-cysteine, a bioactive in aged garlic extract, as an upstream activator of LKB1 that prompts fat tissue to release more eNAMPT. In aged mice, the molecule reduced frailty and improved muscle force. The human data is preliminary.
More
NMN versus NR: what the 2025 evidence actually says
A 2025 Food Frontiers review compares NMN and NR head to head: both raise blood NAD+, but the human trial record falls short of the longevity-extension claims printed on the supplement box.
NMN and NR supplements: what the evidence says about NAD precursors and aging
NAD levels drop by roughly half between age 40 and 70, and supplement companies are selling NMN and NR as the solution. The human trials show measurable NAD increases but inconsistent clinical benefits, and the regulatory situation for NMN remains unsettled.